医師紹介

• Exp Dermatol. 2015;24(2):127-132. Saigusa R, et al. A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis.
• J Dermatol. 2015;42(5):524-527. Saigusa R, et al. Association of anti-RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis.
• Proc Natl Acad Sci USA. 2015;112(49):15136-15141. Saigusa R, et al. Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis.
• J Dermatol. 2016;43(7):808-810. Saigusa R, et al. Association of anti-RNA polymerase III antibody and silicone breast implants in patients with systemic sclerosis.
• Br J Dermatol. 2016;174(2):338-347. Saigusa R, et al. Fli1 deficiency contributes to the downregulation of endothelial protein C receptor in systemic sclerosis: a possible role in prothrombotic conditions.
• Mod Rheumatol. 2017;27(4):618-622. Saigusa R, et al. Plasma plasmin-α2-plasmin inhibitor complex levels may predict the effect of cyclophosphamide for systemic sclerosis-related interstitial lung disease.
• J Invest Dermatol. 2017;137(9):1850-1859. Saigusa R, et al. Systemic Sclerosis Dermal Fibroblasts Suppress Th1 Cytokine Production via Galectin-9 Overproduction due to Fli1 Deficiency.
• Arthritis Res Ther. 2018;20(1):23. Saigusa R, et al. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells.
• Exp Dermatol. 2019;28(5):536-542. Saigusa R, et al. A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis.
• J Dermatol Sci. 2018;89(3):282-289. Saigusa R, et al. Systemic sclerosis complicated with localized scleroderma-like lesions induced by Köbner phenomenon.
• Nat Cardiovasc Res. 2022;1(5):462-475. Saigusa R, et al. Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease.
• Int J Mol Sci. 2022;23(17):9875. Saigusa R, et al. Sex Differences in Coronary Artery Disease and Diabetes Revealed by scRNA-Seq and CITE-Seq of Human CD4+ T Cells.

• J Dermatol. 2016;43(12):1443-1444. Saigusa R, et al. Case of disseminated granuloma annulare with giant plaques.
• Eur J Dermatol. 2017;27(2):200-201. Saigusa R, et al. A case of systemic sclerosis with linear scleroderma developing after fracture surgery.
• Acta Derm Venereol. 2018;98(1):155-156. Saigusa R, et al. Dermatofibrosarcoma Protuberans Presenting as a Large Atrophic Plaque on the Chest.
• J Clin Rheumatol. 2021;27(8S):S668-S669. Saigusa R, et al. A Case of Systemic Sclerosis Complicated With Portal Hypertension.

• Nat Commun. 2014;5:5797. Noda S, Saigusa R, et al. Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis.
• Rheumatology. 2015;54(7):1308-1316. Akamata K, Saigusa R, et al. Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis.
• J Dermatol. 2015;42(5):528-531. Miura S, Saigusa R, et al. Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis.
• J Dermatol. 2015;42(5):461-466. Miura S, Saigusa R, et al. Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis.
• Exp Dermatol. 2016;25(4):287-292. Yamashita T, Saigusa R, et al. A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis.
• Ann Rheum Dis. 2016;75(10):1858-1865. Yoshizaki A, Saigusa R, et al. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells.
• J Exp Med. 2017;214(5):1129-1151. Takahashi T, Saigusa R, et al. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
• Arthritis Rheumatol. 2017;69(9):1879-1890. Fukasawa T, Saigusa R, et al. Contribution of Soluble Forms of Programmed Death 1 and Programmed Death Ligand 2 to Disease Severity and Progression in Systemic Sclerosis.
• J Rheumatol. 2017;44(8):1198-1205. Taniguchi T, Saigusa R, et al. Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
• J Invest Dermatol. 2017;137(5):1057-1067. Yamashita T, Saigusa R, et al. Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis.
• Exp Dermatol. 2017;26(10):912-918. Toyama T, Saigusa R, et al. The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis.
• J Dermatol. 2017;44(10):1168-1171. Miyagawa T, Saigusa R, et al. Serum H-ficolin levels: Clinical association with interstitial lung disease in patients with systemic sclerosis.
• Exp Dermatol. 2018;27(4):418-425. Hirabayashi M, Saigusa R, et al. Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis.
• Exp Dermatol. 2018;27(9):1030-1037. Taniguchi T, Saigusa R, et al. CXCL13 produced by macrophages due to Fli1 deficiency may contribute to the development of tissue fibrosis, vasculopathy and immune activation in systemic sclerosis.
• J Dermatol Sci. 2018;92(3):207-214. Saigusa R, et al. Progranulin overproduction due to constitutively activated c-Abl/PKC-δ/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-α in localized scleroderma.
• J Dermatol Sci. 2019;93(1):24-32. Yamashita T, Saigusa R, et al. Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis.
• J Invest Dermatol. 2019;139(5):1150-1160. Yamashita T, Saigusa R, et al. Cyclophosphamide Pulse Therapy Normalizes Vascular Abnormalities in a Mouse Model of Systemic Sclerosis Vasculopathy.
• J Dermatol. 2019;46(7):584-589. Fukui Y, Saigusa R, et al. Possible association of decreased serum CXCL14 levels with digital ulcers in patients with systemic sclerosis.
• Rheumatology. 2020;59(8):2005-2014. Miyagawa T, Saigusa R, et al. Fli1 deficiency induces endothelial adipsin expression, contributing to the onset of pulmonary arterial hypertension in systemic sclerosis.
• Arthritis Rheumatol. 2020;72(12):2110-2122. Nakamura K, Saigusa R, et al. Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-like Vasculopathy in KLF5+/−;Fli-1+/− Mice.
• J Exp Med. 2021;218(3):e20200551. Marki A, Saigusa R, et al. Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis.
• Exp Dermatol. 2021;30(3):409-415. Omatsu J, Saigusa R, et al. Serum S100A12 levels: Possible association with skin sclerosis and interstitial lung disease in systemic sclerosis.
• Front Cardiovasc Med. 2022;8:812769. Nettersheim FS, Saigusa R, et al. Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B.
• BMC Biol. 2022;20:193. Vallejo J, Saigusa R, et al. Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells. ※共同筆頭
• Front Immunol. 2023;14:1239148. Iqneibi S, Saigusa R, et al. Single cell transcriptomics reveals recent CD8 T-cell receptor signaling in patients with coronary artery disease.
• JCI Insight. 2023;8(14):e171359. Slysz J, Saigusa R, et al. Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes.
• Nat Cardiovasc Res. 2023;2(10):1003-1014. Pattarabanjird T, Saigusa R, et al. Human circulating CD24hi marginal zone B cells produce IgM targeting atherogenic antigens and confer protection from vascular disease.

• J Dermatol. 2017;44(3):e54-e56. Miyagawa T, Saigusa R, et al. Pazopanib induced a partial response in a patient with metastatic fibrosarcomatous dermatofibrosarcoma protuberans without genetic translocations resistant to mesna, doxorubicin, ifosfamide and dacarbazine chemotherapy and gemcitabine-docetaxel chemotherapy.
• J Dermatol. 2017;44(11):e302-e303. Miyagawa T, Saigusa R, et al. Multiple-opposing rotation flaps for the scalp defect including hair whorl.

• Curr Opin Immunol. 2019;59:15-24. Kobiyama K, Saigusa R, et al. Vaccination against atherosclerosis.
• J Dermatol Sci. 2019;94(2):259-265. Asano Y, Saigusa R, et al. Systemic sclerosis: Is the epithelium a missing piece of the pathogenic puzzle?
• Nat Rev Cardiol. 2020;17(7):387-401. Saigusa R, et al. T cell subsets and functions in atherosclerosis.
• Clin Chem. 2020;66(6):751-753. Saigusa R, et al. CITE-Seq Hits Vascular Medicine.
• Methods Mol Biol. 2023;2582:185-196. Saigusa R, et al. Single-Cell Antibody Sequencing in Atherosclerosis Research.

• 2014年｜ACR/ARHP Annual Meeting Saigusa R, et al. Loss of IRF5 Ameliorates Tissue Fibrosis in a Murine Model of Systemic Sclerosis. Poster presentation. Boston, USA. Abstract No. 1724.
• 2015年｜ACR/ARHP Annual Meeting Saigusa R, et al. Fli1 Deficiency Contributes to the Downregulation of Endothelial Protein C Receptor in Systemic Sclerosis: A Possible Role in Pro-Thrombotic Condition. Poster presentation. Boston, USA. Abstract No. 3009.
• 2016年｜ACR/ARHP Annual Meeting Saigusa R, et al. Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells. Poster presentation. Washington, DC, USA. Abstract No. 2072.

大学病院皮膚科をはじめとする診療経験の中で、以下のような皮膚科手術・処置に携わってきました。診療内容や対応可能な治療は、疾患の状態や院内設備などによって異なります。

腫瘍切除術（良性腫瘍）

• 粉瘤（表皮嚢腫）摘出術
• 脂肪腫摘出術
• 脂腺母斑切除術
• 脂漏性角化症切除術
• 軟性線維腫切除術
• 色素性母斑切除術
• 青色母斑切除術
• 汗管腫切除術
• 血管腫切除術
• 神経線維腫切除術
• 石灰化上皮腫摘出術
• 毛包腫瘍切除術

腫瘍切除術（悪性腫瘍）

• 基底細胞癌切除術
• 有棘細胞癌切除術
• 悪性黒色腫広範囲切除術
• ボーエン病切除術
• 日光角化症切除術
• 乳房外Paget病切除術
• Merkel細胞癌切除術
• 隆起性皮膚線維肉腫切除術
• 皮膚リンパ腫生検・切除
• 転移性皮膚腫瘍切除術

生検

• パンチ生検
• 切開生検
• 切除生検
• 楔状生検
• 粘膜生検
• 爪生検
• 毛髪生検
• センチネルリンパ節生検（悪性黒色腫）

再建術

• 単純縫縮
• 局所皮弁形成術
• Advancement flap
• Rotation flap
• Transposition flap
• Rhomboid flap
• Bilobed flap
• V-Y flap
• Limberg flap
• 全層植皮術（FTSG）
• 分層植皮術（STSG）
• 人工真皮併用植皮
• 二次再建術

レーザー治療

• 炭酸ガスレーザー
• Qスイッチルビーレーザー
• Alexandriteレーザー
• Nd:YAGレーザー
• 色素レーザー
• Er:YAGレーザー
• フラクショナルレーザー

レーザー治療の対象疾患

• 母斑
• 色素斑
• 血管腫
• 疣贅
• 汗管腫
• 脂漏性角化症

電気外科・凍結療法

• 電気焼灼術
• 電気凝固術
• 高周波メス
• 電気乾固
• 液体窒素療法
• Cryosurgery

凍結療法の対象疾患

• 尋常性疣贅
• 日光角化症
• 脂漏性角化症
• 軟属腫

爪手術

• 陥入爪手術
• 巻き爪手術
• 部分抜爪術
• 全抜爪術
• 爪母切除術
• フェノール法
• 爪甲形成術

膿瘍・感染症に対する処置

• 切開排膿術
• デブリードマン
• 瘻孔切除
• 異物摘出

瘢痕・形成手術

• ケロイド切除術
• 肥厚性瘢痕切除術
• Z形成術
• W形成術
• 瘢痕形成術

腋臭症・多汗症に対する手術

• 腋臭症手術
• 皮下組織掻爬法
• 剪除法
• 反転剪除法

毛髪・毛包に関する手術・検査

• 毛包生検
• 毛髪移植（施設による）
• 毛包腫瘍摘出術

その他の手術・処置

• 異物摘出術
• ピアス孔形成
• ピアス異物除去
• ドレナージ術
• 皮膚縫合術
• 抜糸
• 創傷処置
• VAC療法管理
• 難治性潰瘍デブリードマン

大学病院皮膚科で比較的経験することが多い手術

• 粉瘤摘出術
• 脂肪腫摘出術
• 色素性母斑切除術
• 基底細胞癌切除術
• 有棘細胞癌切除術
• 悪性黒色腫広範囲切除術
• 乳房外Paget病切除術
• パンチ生検
• 切除生検
• 全層植皮術
• 分層植皮術
• 局所皮弁形成術
• センチネルリンパ節生検
• 液体窒素療法
• 炭酸ガスレーザー治療
• 電気焼灼術
• 陥入爪手術
• 腋臭症手術
• ケロイド切除術